Thiol-disulfide homeostasis in children with febrile neutropenia
Elif Güler Kazancı, Deniz Guven, Ayse Oren, Yasemin Ustundag, Ozcan Erel, Funda Eren
DOI: 10.55358/atjmed.2022.05.06 · Page: 20-4 · 46 Views · 3 Downloads · 0 Citations
Abstract
Aim: The body’s antioxidant system processes rely on thiol-disulfide equilibrium to function correctly. The purpose of this study was to look into dynamic thiol/disulfide homeostasis (TDH) as an endogenous antioxidant indicator in febrile neutropenic (FN) children with acute lymphoblastic leukemia (ALL).
Materials and methods: The study included 66 acute lymphoblastic leukemia patients, including 33 with FN and 33 controls. Both groups were compared for TDH and ischemia-modified albumin (IMA). TDH parameters were assessed using a unique spectrophotometric approach disclosed earlier by Neşelioğlu and Erel.
Results: Total thiol, native thiol, disulfide, and native thiol/total thiol levels were significantly lower in patients with FN than in the controls (p< 0.05). Disulfide/total thiol, disulfide/native thiol, and IMA levels were significantly higher in the FN group than in controls (p<0.05).
Conclusions: TDH could be a simple tool that could be used in routine screening as an indicator of thiol-specific oxidative stress, particularly in pediatric febrile neutropenia.
Keywords : Thiol/disulfide homeostasis; oxidative stress; febrile neutropenia; acute lymphoblastic leukemia